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The passage of time causes cells to age, decreasing the synthesis of many of those essential for maintaining youthful skin. As such, there is a reduction in the production of hyaluronic acid (HA), responsible for the level of tissue hydration, and epidermal growth factor (EGF), essential for epidermal regeneration, giving rise to dreaded skin ageing. Over the years, synthesis of hyaluronic acid in the body reduces and degradation increases. The result is a loss of volume, a sagging facial contour and wrinkles, giving the face an old and tired appearance. The decrease in the amount of epidermal growth factor in the body results in reduced cellular activation and therefore a decrease in collagen and elastin production. Consequently there is a loss of elasticity and firmness, and wrinkles and weak skin appear. This is why we, at Dermica Laboratoires, have developed EGF REGENERATION CREAM, a new biotech cosmetic product formulated using Hyaluronic Acid (HA) and Epidermal Growth Factor (EGF), which has proved highly effective in treating wrinkles and signs of ageing.

HA
Also known as Sodium Hyaluronate, HA is a molecule (polysaccharide) that is naturally present in our body, in the epidermis and in different types of mucous membranes. It acts as a component in the spaces between tissue cells and forms part of what is known as the extracellular matrix, or ECM, which facilitates the lubrication, absorption and transportation of basic nutrients to cells and the elimination of waste. Reitergasse nº 1, 2nd floor, 8004 Zurich / Switzerland. 150825 info@dermica.ch Hyaluronic acid is a glycosaminoglycan (GAG). GAGs may give rise to more complex and

larger formations, making up large molecular structures such as proteoglycans. Proteoglycans that are formed from or contain hyaluronic acid are normally found in the body's connective tissues, such as the skin and cartilage, as the main mechanism of action of hyaluronic acid chains is the absorption of water in order to maintain optimum levels of hydration in those tissues. As such, HA molecules have a high ability to attract water molecules and, in turn, are
able to expand and to withstand heavy compression. As well as being an excellent skin moisturiser, hyaluronic acid has a number of .

other properties that make it unique:

- Skin hydration
- Firms and softens the skin (thanks to the lubrication of collagen fibres)
- Enhances and maintains the skin's defensive barrier (ability to impede movement of certain pathogens)
- Slows down skin ageing

EGF (Epidermal Growth Factor) Epidermal Growth Factor (EGF) plays a part in the majority of epithelial regeneration processes. It is a polypeptide consisting of 53 amino acids with a molecular weight of 6.2
Da, which has been shown to play an important role in epidermal development. It acts directly by stimulating the proliferation of epidermal cells without being subjected to any other influence or hormonal or systemic
condition.

Properties of Epidermal Growth Factor:

- Prevents and improves signs of ageing (wrinkles, age spots, loose skin...)
- Acts as a bio-revitaliser

Uses

- As it aids skin regeneration, it can be used in the process of wound healing
- Improves appearance of stretch marks
- Whenever there is a need for epidermal repair (after a peel, implants...)
- Following laser or IPL treatment
- Revitalisation. Restores skin vitality, improving cellular physiology
- Anti-ageing (reduces oxidative stress). Improves cell function because of its antioxidant action

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