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The CEGABA activity as a promoter of cell growth has been demonstrated in several studies carried out first by Curti and Fussi, and later by G.Forni and J. Guardiola. A study published in the Journal of Immunological Methods by Cerino A, de Amici M, Fussi FF, AStaldi Ricotti GC, about CEGABA as a growth factor for hybridomas, achieved the following conclusions. CEGABA (carboxyethyl gamma-aminobutyric acid), a molecule derived from polyamines,
causes an increase in the proliferation of Hybridomas in vitro. Compared to other growth factors, the effects and mechanism of action of CEGABA and CRECGS (endothelial cell growth supplement) on Hybridomas growth are of a similar nature. However, both factors are less effective than HECS in inducing growth of hybridoma through every step of hybridoma production, including: recovery after the merger, donation and proliferation. This shows that they can act as growth factors in a general and less specific way than in the case of HECS.

 PROCEDURE:

The tests were conducted in subjects from different social and cultural background.
During the preliminary interviews those subjects who seemed to be too worried about their hair characteristics were rejected.
Some of the subjects where explained the scientific basis of this study, while the rest were not given any technical explanations.

MATERIALS:

A cosmetic formula with the following ingredients was used:
-CEGABA (1gr.)
-Ethanol 7,5 cc.
-Propileneglicol 1cc
-Parfume
-Dye
-Water

RESULTS :
We obtained very good results in the group of men from 18 to 30 years where 4 out of 5, showed a remarkable response to the treatment (irrespective of the high percentage of subjects who did not attend the controls).
In the female group excellent results were also obtained; in this case, and in all cases except for four women who did not attend the controls, as first result we obtained a stop in the hair loss (objective data) and also all of them commented on having noticed an increase in capillary volume and a thickening of the hair, 'which was confirmed by their hairdressers. In two cases there was considerable growth of new hair in the temple area, which was easily
verifiable since both subjects had undergone a process of dyeing or bleaching hair. Results were less evident in the group of men aged 45 to 60 years. Only 5 subjects in a group of 9 (one of them did not attend the control) commented having noticed a strengthening of the hair and 3 of them proved these effects with objective data. The other four subjects indicated a reduction in hair loss as much as strengthening in the hair impression.
It should be noted that this group was the most difficult to control objectively. In none of the cases intolerance or allergic reactions appeared.

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